Yes, this is possible because all Transloadit robots ignore any files they cannot handle. Therefore, you can set up two Steps with different robots that have use: ":original" specified, and the files will be automatically routed appropriately based on filetype. For example, if the uploaded file is an image, it can be resized and stored. If it is a video, it can be video encoded and have thumbnails extracted and stored. If it is a Word document or spreadsheet it can just be stored, etc.